Study of the role of the stress system in the development of severe forms of psoriasis (Case Report)

Abstract

The purpose of the study was to follow the casual mechanism of exacerbation, progression and formation of severe forms of psoriasis, as well as the progression of cutaneous manifestation of psoriasis with the definition of the role of stress response in their development by analyzing features of the psoriasis dynamics on the example of reviewing clinical case in anamnesis.Examination of the psychosomatic condition and stress-making immunoneuroendocrine system of the patient with psoriasis was conducted at the beginning of disease and in the remission period of psoriasis. In the patient’s blood serum the concentration of trigger cytokins (IL-1β, IL-8, IL-10, IL-17, TNFα), stress hormones – ACTH and cortisol, the states of cell-humoral immunity (CD3, CD4, CD8, CD16, CD22, immunoregulatory index, Levels of IgM, IgG) were identified.The results of the study confirm the activation of the stress-system during psoriasis, in particular by elevation of levels of IL-8, IL-10, TNFα, ACTH, cortisol along with the decrease of levels of IL-1β, IL-17, which indicates the tension of the stress-making mechanisms of the patient with psoriasis in spite of clinical stabilization of cutaneous process. Conclusions. Therefore the above mentioned indications appear to be key mediators of stress-making immunoneuroendocrine system and play an equivocal role in the development of the severe form of psoriasis. Their diverse effects require further investigation.