Allelic Polymorphism of FDPS Gene in Prognosis of Osteoporosis in Young Patients with Osteoarthritis

Abstract

In young patients with OA often deter- mined violation of the structure of bone tissue, leading to the formation of osteopenia (11 patients — 34.4 %) or os- teoporosis (12 — 37.5 %). Development of such changes in bone tissue occurs against pathological mutation of the FDPS gene (genotype C/C). Thus, the study variants of the FDPS gene in patients with OA can be used as a marker for the formation of osteoporosis, which allows to develop measures for its prevention.