Personalized treatment selection in a patient with symptomatic hereditary thrombophilia and hyperhomocysteinemia
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Abstract
The article illustrates the clinical observation of a patient with recurrent thrombosis of the lower extremities and hyperhomocysteinemia, has been selected personalized therapy based on the results of molecular genetic surveys.
Description
The research of genes’ polymorphisms of cardiovascular diseases’ susceptibility gets great practical meaning in modem stage of molecular medicine development. Last decade was marked by significant growth of research, dedicated to hyperhomocysteinemia (HHC) as one of the reasons which causes the development of thrombophilia [1,2]. Homocysteine (HC) has an evident toxic effect that is developed, first of all, in violation of endothelial function, that’s why the increasing of HC level in blood has evident atherogenic and thrombophilic effects. The last ones are caused by toxic HC metabolites which damage vessels’ endothelium, baring subendothelial matrix and smooth muscle cells, that stimulates thrombocyte aggregation and thrombogenesis [3].
Citation
Vasyliev D. V. Personalized treatment selection in a patient with symptomatic hereditary thrombophilia and hyperhomocysteinemia / D. V. Vasyliev, O. V. Vasylieva // International Scientific Bridge East-West: Contemporary Trends of Science and Practice = Международный научный мост Восток-Запад: современные тенденции науки и практики : International Scientific-Practical Conference, London, 02.03.2015 : collection of conference papers / Centre for Scientific and Practical Studies. – London, 2015. – Р. 14–16.