Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction
dc.contributor.author | Kopytsya, Mykola | |
dc.contributor.author | Hilova, Yaroslava | |
dc.contributor.author | Rodionova, Yuliia | |
dc.contributor.author | Polivenok, Igor | |
dc.contributor.author | Shelest, Borys | |
dc.date.accessioned | 2021-11-25T09:35:30Z | |
dc.date.available | 2021-11-25T09:35:30Z | |
dc.date.issued | 2021-05 | |
dc.description.abstract | Aim: The aim of the study was to investigate the relationship between the soluble suppression of tumorigenicity 2 (sST2) level and the degree of epicardial blood flow recovery in patients with myocardial infarction with ST-segment elevation (STEMI) after percutaneous coronary intervention. Material and Methods: The study involved 61 patients (83.6% males), with a mean age of 59.85±10.01 years. sST2 level was measured by enzyme immunoassay. Patients were divided into two groups. The first group (n=12) included patients with thrombolysis in myocardial infarction (TIMI) ≤II flow grade, the second group (n=49) with TIMI III flow grade. Results: The sST2 level was significantly higher in the first hours of the disease in the group with decreased epicardial blood flow (TIMI ≤II) after percutaneous coronary intervention (p=0.003). Receiver operating characteristics curve analysis showed that sST2 levels over 34.2 ng/ml, detected on admission, was an independent predictor of adverse revascularization (TIMI ≤II) in patients with STEMI with a sensitivity of 92.3% and a specificity of 62.5%; the area under curve was 0.811 (95% CI: 0.651 - 0.873; p=0.001). Both the univariate (OR: 1.020, 95% CI: 1.001-1.041, p=0.028) and multivariate (OR: 1.030; 95% CI: 1.002-1.057; p=0.033) analyzes showed that sST2 was a significant predictor of the unfavorable outcome of epicardial vascular revascularization (TIMI ≤ІІ). Conclusion: sST2 is highly associated with the degree of blood flow recovery after percutaneous coronary intervention in patients with STEMI and is of great clinical importance as a prognostic marker. | en_US |
dc.identifier.citation | Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction / M. Kopytsya, Y. Hilova,Y. Rodionova, I. Polivenok, B. Shelest // Duzce Medical Journal. ꟷ 2021. ꟷ N 2 (23). ꟷ Р. 174ꟷ180. | en_US |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/29930 | |
dc.language.iso | en | en_US |
dc.relation.ispartofseries | doi;10.18678/dtfd.889947 | |
dc.subject | acute myocardial infarction | en_US |
dc.subject | sST2 | en_US |
dc.subject | no-reflow phenomenon | en_US |
dc.subject | percutaneous coronary intervention (PCI) | en_US |
dc.title | Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction | en_US |
dc.type | Article | en_US |
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