High nitric oxide level is a factor of esophageal alterations in patients with Bechterew’s disease

Abstract

Overproduction of NO in patients with BB leads to its accumulation in the organism. On the one hand, NO reduces the tone of the lower esophageal sphincter and 151 contributes to GERD. On the other hand, NO is partially transformed into peroxynitrite. Peroxynitrite causes degradation of proteins and inactivates the enzyme superoxide dismutase increases lipid peroxidation. Thus, disturbances of esophageal motility (problem with lower esophageal sphincter) are compounded by cytotoxic effect on the cellular and molecular level.