Analysis of interleukins spectrum in indused sputum in children with pulmonary diseases

Abstract

This article has been performed the investigation of immunity system characteristics in children with bronchitis. There has been identified factors of unfavourable prognosis of bronchitis transformation in other chronic lung diseases, which include disorder of cytokines-synthesis. A study was undertaken to determine the airway and lung inflammation, by analysing cytokines in the induced sputum from 38 children with the acute bronchitis, 35 patients with the acute pneumonia, 15 children with the chronic lung disease, which had lung fibrosis, and 18 healthy children. Sputum levels of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in all groups were statistically significantly increased compared with normal controls. Changes of interleukins spectrum in induced sputum of patient with bronchitis and pneumonia we can use in clinical as the risk subgroup of patients with chronic lung diseases.