Pathogenetic links of the combined course of chronic pancreatitis and hypertensive disease and their role in the formation of complications

Abstract

Objective the purpose of the study the relationship between the gene polymorphism of vitamin D receptors (VDR) and biochemical markers of bone metabolism in the risk of osteoporosis in patients with chronic pancreatitis (CP) and hypertensive disease (HD). 110 patients with CP were examined, in which it proceeded against the background of HD in 70 cases, and in 40 cases it was isolated. The polymorphism of the VDR gene, the content of osteocalcin, total acid phosphatase (TAP), and tartrate-resistant acid phosphatase (TRAP) were studied to determine the possible effect of these parameters on the course of the disease and the formation of complications. The obtained results show that in persons with combined course of CP and HD, a decrease in serum osteocalcin content (bone tissue synthesis index) and an increase in the content of TAP and TRAP - markers of bone destruction were revealed. The polymorphism of the VDR gene was characterized by the predominance of individuals with the B-allele, against which the reliability of changes in biochemical markers of osteoporosis was noted, which can be considered as a predictor of the development of osteoporotic conditions. The combined course of CP and HD is characterized by an increase in the number of persons with B-alleles of the VDR gene (84.3%), the carriers of which have an increased risk of osteopenic conditions. Reduction of osteocalcin content, increase in the level of TAP and TPKF in the blood serum of patients with HP and HD often occur against the background of an unfavorable Ballele of VDR gene polymorphism. Combined course of CP and HD is the basis for early diagnosis of secondary osteoporosis. Keywords: chronic pancreatitis, hypertensive disease, vitamin D receptor gene, biochemical markers of osteoporosis, osteopenic condition