Характер взаимоотношений системы простагландинов, окситоцина и тропных гормонов при пубертатных маточных кровотечениях

Abstract

The data obtained in the study testify to the involvement of prostaglandins (PG) and oxytocin (Ot) in the pathogenesis of pubertal uterine bleeding (PUB). In most of our patients we observed disorders in PG and Ot production. Only in a third of patients PG and Ot levels were within the physiologic range of values. As for Ot and pressor PGF2α levels, they were mainly reduced, and PGE2 levels were elevated. The character of relations of PG and Ot with gonadotropic hormones and prolactin, revealed in the study, pointed out a ignificant loss of reserve mechanisms in the central regulation of patients with PUB.