Значение гормонов жировой ткани в патогенезе сахарного диабета 2 типа у больных с постинфарктным кардиосклерозом

Abstract

The role of adipose tissue hormones in the pathogenesis of type 2 diabetes in patients with postinfarction cardiosclerosis was estimated in the present article. Results and discussion. The course of postinfarction cardiosclerosis was accompanied by an imbalance of adipocytokines and increasing degree of insulinresistance, which depend on the presence of type 2 diabetes. In patients with postinfarction cardiosclerosis and type 2 diabetes level of vaspin was higher on 32.30% than in patients without diabetes, amounting to 623,769 ± 2,194 pg/ml, and the level of omentin was less on 19.03% to 420,760 ± 1,226 ng/ml. Conclusions: presence of type 2 diabetes leads to increase of serum vaspin and decrease of serum omentin in patients with postinfarction cardiosclerosis according to the degree of insulinresistance. The adipose tissue hormones imbalances in patients with postinfarction cardiosclerosis is relatively independent primary factor in the formation of type 2 diabetes, and the level omentin may factor of progression of metabolic disorders and increasing severity of diabetes.