Polymorphism of the renin-angiotensin system genes and endothelial no-synthase gene in obese patients with arterial hypertension
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Date
2018-12
Authors
Ashcheulova, Tetyana
Gerasimchuk, Nina
Demydenko, Ganna
Kulikova, Mariia
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The review is dedicated to relationships between the blood pressure and body mass. Endothelial
dysfunction and imbalance of neurohumoral systems, namely, the pathological increase in the
activity of the renin-angiotensin system, in combination with obesity are the main mechanisms
of the of the hypertonic disease pathogenesis. Here we discuss the research on polymorphism
of the renin angiotensinic system genes and the endothelial synthase nitric oxide gene. The
difficulty lies in the correct assessment of associations of alleles which have clinical signifi-
cance. It is essential to determine precisely the associations of gene polymorphisms in the
hypertonic disease with obesity. This provides an opportunity to identify new personified
approaches to the treatment of patients with this complex pathology.
Description
Keywords
endothelial nitric oxide synthase, renin-angiotensin system, gene polymorphism, hypertonic disease, obesity
Citation
Polymorphism of the renin-angiotensin system genes and endothelial no-synthase gene in obese patients with arterial hypertension / T. V. Ashcheulova, N. N. Gerasimchuk, G. V. Demydenko, M. V. Kulikova // Biopolymers and Cell. – 2018. – Vol. 34, N 5. – P. 331–349. – doi: http://dx.doi.org/10.7124/bc.000988.