Level of tnf-α, stnf-ri and 8-isoprostane in the combined therapy of fosinopril and hydrochlorothiazide at overweight hypertensive patients
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Date
2016-09-21
Authors
Ashcheulova, Tetyana
Kovalyova, Olga
Gerasimchuk, Nina
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Abstract
One of the manifestations of the pathogenesis of such combined pathology as hypertension (AH) and obesity is the development of endothelial dysfunction (ED). Recent studies suggest a possible role of immune-inflammation activation mediated by pro-inflammatory cytokines, and oxidative stress (OS) in the development of ED.
Aim. Assessment of the level of TNF-α, sTNF-RI and 8-isoprostane, as the main marker of OS, at overweight patients with arterial hypertension in combined fosinopril 20 mg and hydrochlorothiazide 12.5 mg (fozid-20).
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Keywords
pro-inflammatory cytokines, oxidative stress, sTNF-RI, TNF-α
Citation
Ashcheulova T. V. Level of tnf-α, stnf-ri and 8-isoprostane in the combined therapy of fosinopril and hydrochlorothiazide at overweight hypertensive patients : матеріали XVII Національного конгресу кардіологів України, Київ, 21–23 вересня 2016 р. / T. V. Ashcheulova, O. N. Kovalyova, N. N. Gerasimchuk // Український кардіологічний журнал. – 2016. – Додаток 3. – С. 80–81.