Correlation between vascular remodeling and level of adipokine visfatin in hypertensive patients combined with abdominal obesity

Abstract

Aim of the study is to optimize diagnosis of hypertensive patients combined with abdominal obesity (AO) and without it based on the determined effect of visfatin on vascular lesions. Methods. A total patients were completed 84 hypertensive patients which were separated on the first group patients with hypertension (n=25) and the second group of hypertensive patients with AO (n=59), the third group were control of apparently healthy individuals (n=17). Patients matched for age and sex. ELISA «RayBioteeh», USA was determined the level of visfatin in the serum. Structural condition of the common carotid artery evaluated by measuring the intima-media complex (IMC) of common carotid artery (CCA) used the echocardiography on the diagnostic complex «Ultrasound scanner» (USA). . Result. The systolic blood pressure (SBP) was completed (177,8±3,7) mm Hg for hypertensive patients with abdominal obesity and hypertensive patients for (166,4±2,9) mm Hg (p<0.05). In patients with abdominal obesity the level of visfatin significantly different from the control group by (33,9±1,47) ng/ml and (17,51±0,96) ng/ml (p<0.05), while in the group of hypertensive patients (24,27±1,2) ng/ml, significant differences were not found. Visfatin levels in hypertensive patients with AO (25,43±1,48) ng/ml, in contrast to patients with hypertension (19,49 ± 1,16) ng/ml, even at normal of IMC of the CCA were significantly different from the control group (p<0.05). Established a positive correlation between visfatin and IMC of the CCA in hypertension with abdominal obesity (r=0,49) and without (r=0,41), p <0,05. Conclusion. The results shows that elevated serum visfatin levels are early lesion of the vascular bed makes higher levels of visfatin compared with the control group with hypertension and AO on a background of normal IMC of the vascular wall.