Surfactant protein C genetic polymorphism in patients with occupational COPD is associated with right ventricle changes

Abstract

Individual peculiarities are taken into account in development of chronic obstructive pulmonary disease (COPD). The role of surfactant protein C (SFTP-С) genetic polymorphism is known in development of irreversible bronchial obstruction component as most typical feature of COPD. However, relation of SFTP-С to cardiological consequences of COPD was not studied enough. Aims and objectives: Investigation of relation of SFTP-С genetic polymorphism with development of right heart hypertrophy and dysfunction, estimation of prophylactic potential of clinical-genetic investigation in workers exposed to dust. In 42 male Caucasian workers from machine-building industry 51,3±14,42 years old COPD of 2nd stage according to GOLD (2010) was diagnosed. Genotypes of SFTP-С: А138С and А186G were investigated in polymerase chain reaction with following mass spectrometry analysis. Morphofunctional state of heart was defined echocardiographically. It was stated that А138С and А186G polymorphisms of SFTP-С gene are connected with right heart changes. E.g., СС genotype is associated with right ventricle hypertrophy, GG genotype – with decrease of right ventricle pre-expulsion (p<0,01). This may be explained by determinant role of certain SFTP-С phenotypes in pulmonary fibrosis, emphysema, further disturbances of circulation and increased right ventricle pre-load. Evaluation of SFTP-С genetic polymorphism in workers of dust-related occupations has a perspective of introduction as a prognostic marker in prophylaxis of COPD cardiovascular complications.

У когортному проспективному досліджені доведено, що оцінка генетичного поліморфізму сурфактантного білку С у робітників пилових професій має перспективи впровадження в якості прогностичного маркера у профілактику хронічного обструктивного захворювання легенів та його серцево-судинних ускладнень.

В когортном проспективном исследовании доказано, что оценка генетического полиморфизма сурфактантного белка С у рабочих пылевых профессий имеет перспективы внедрения в качестве прогностического маркера в профилактику хронической обструктивной болезни легких и его сердечно-сосудистых осложнений.