Allelic Polymorphism of FDPS Gene in Prognosis of Osteoporosis in Young Patients with Osteoarthritis

Abstract

In young patients with OA often deterined violation of the structure of bone tissue, leading to the formation of osteopenia (11 patients — 34.4 %) or osteoporosis (12 — 37.5 %). Development of such changes in bone tissue occurs against pathological mutation of the FDPS gene (genotype C/C). Thus, the study variants of the FDPS gene in patients with OA can be used as a marker for the formation of osteoporosis, which allows to develop measures for its prevention.