Тадеуш Рейхштейн: від погромів – до кортизону, вітаміну С і відкриття глюкокортикоїдів

Abstract

The article presents modern information about the synthesis of glucocorticoids, their mechanisms of action, features of pharmacokinetics and pharmacodynamics. Particular attention is paid to the discoverers of glucocorticoids and steroid hormones in general. Increasing knowledge of the biology of glucocorticoids and glucocorticoid receptors is associated with a better understanding of the molecular mechanisms underlying their clinical applications. A historical analysis of modern ideas about the biology of glucocorticoids is presented, with an emphasis on synthesis, regulation and physiology.