State of the Blood-Air Barrier in Pediatric Acute Leukemia patients: prognosis for pulmonary complications

Abstract

The blood-air barrier (BAB) is a structural and functional part of the lungs, which is composed of epithelial, interstitial, and endothelial components. Studied markers IL-6, TGF-β in exhaled breath condensate (EBC) and serum VEGF-A are increased both during protocol treatment and in long-term remission, which proves BAB damage in children with acute leukemia (AL). Levels of IL-6 and TGF-β in EBC and VEGF-A in serum can be predictive for lung complications in pediatric acute leukemia patients. Assessment of BAB damage markers can be useful for the management of children with AL to provide timely and effective care.