State of the Blood-Air Barrier in Pediatric Acute Leukemia patients: prognosis for pulmonary complications

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Date

2023

Authors

Makieieva, Natalia
Koval, Victoria

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Abstract

The blood-air barrier (BAB) is a structural and functional part of the lungs, which is composed of epithelial, interstitial, and endothelial components. Studied markers IL-6, TGF-β in exhaled breath condensate (EBC) and serum VEGF-A are increased both during protocol treatment and in long-term remission, which proves BAB damage in children with acute leukemia (AL). Levels of IL-6 and TGF-β in EBC and VEGF-A in serum can be predictive for lung complications in pediatric acute leukemia patients. Assessment of BAB damage markers can be useful for the management of children with AL to provide timely and effective care.

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Keywords

acute leukemia, pneumonia, children, pulmonary complications, blood-air barrier, cytokines, interleukin-6, transforming growth factor β, vascular endothelial growth factor, 2023а

Citation

Makieieva N. I. State of the Blood-Air Barrier in Pediatric Acute Leukemia patients: prognosis for pulmonary complications / N. Makieieva, V. Koval // Hematology/Oncology : 8th Kaunas/Lithuania International Colloquium, 12 th May, 2023, Kaunas, Lithuania : Online Poster Abstract Book. – Kaunas, 2023. ─ P. 15─17.

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