Activity of glutathione enzyme system in students with gastroesophageal reflux disease

Abstract

The course of GERD in students is characterized by the presence of predisposing factors for both its occurrence and progression. Unbalanced day under load, chronic stress, lack of timely food intake, poor qual- ity food, admiration for carbonated and low alcohol drinks, and accumulation in large groups with frequent respiratory diseases lead to stress on the body’s protective systems and contribute to oxidative stress. Exacerba- tion of GERD in students leads to impaired antioxidant defense by suppressing the activity of key glutathione system components—glutathione peroxidase, glutathione reductase, and reduced glutathione. This may contrib- ute to both prolonged disease exacerbation and the chronic progression of the pathology.