IL-1β and IL-10: diagnostic and prognostic potential of cytokines in the assessment of progression of non-alcoholic fatty liver disease in patients with hypertension

dc.contributor.authorRozhdestvenska, Anastasiia
dc.contributor.authorZhelezniakova, Natalia
dc.date.accessioned2021-11-18T13:30:39Z
dc.date.available2021-11-18T13:30:39Z
dc.date.issued2021-09
dc.description.abstractIntroduction. Non-alcoholic fatty liver disease (NAFLD) affects about a quarter of the world's population and is closely linked to hypertension (HT). Pro-inflammatory and anti-inflammatory cytokines play a key role in the pathology progression, and the search for non-invasive biomarkers for the diagnosis of NAFLD remains an important issue. The objective of the study was to determine the diagnostic and prognostic value of IL-1β and IL-10 in assessing the progression of liver parenchyma changes in patients with NAFLD and HT comorbidity. Materials and methods. A study of 115 patients with non-alcoholic steatohepatitis (NASH) was performed. The main group consisted of 63 patients with NASH and HT, 52 patients with isolated NAFLD represented the comparison group. Clinical and laboratory parameters were evaluated, IL-10 and IL-1β levels were measured by ELISA method, ultrasound steatometry and elastography were performed in all patients. Results. The attenuation coefficient and median liver stiffness in NAFLD and HT group significantly exceeded the results in the isolated NAFLD group and in the control group. The IL-1β level in NAFLD and HT group was 4.76 pg/ml, and in isolated NAFLD group the indicator averaged 4.02 pg/ml, which exceeded the control values (0.59 pg/ml). IL-10 level was 2.69 ng/ml and 4.90 ng/ml in patients with comorbid and isolated NAFLD, respectively, while control results averaged 8.17 ng/ml. It were found strong relationship between IL-1β, IL-10 and CRP levels in patients with NAFLD and HT (r = 0.61 and r = -0.69, respectively) Inverse correlations were also found between the cytokines IL-1β and IL-10 in NAFLD patients with and without HT (r = -0.61 and r = -0.57, respectively). Changes in the cytokine status of patients with NAFLD at different stages of steatosis and liver fibrosis have been identified. Conclusions. The presence of concomitant HT in patients with NAFLD is associated with greater severity of liver parenchyma changes. NAFLD manifestation is accompanied by increase of IL-1β and decrease of IL-10 levels, and deepening of these deviations were found in patients with comorbidity of NAFLD and HT. Interleukins IL-1β and IL-10 can be defined as biomarkers of NAFLD progression both in its isolated course and in its comorbidity with HT. The possibility of using biomarkers as an independent non-invasive test of diagnosing NAFLD requires futher study.en_US
dc.identifier.citationZhelezniakova N. IL-1β and IL-10: diagnostic and prognostic potential of cytokines in the assessment of progression of non-alcoholic fatty liver disease in patients with hypertension / N. Zhelezniakova, A. Rozhdestvenska // EUREKA : Health Sciences. – 2021. – № 5. – P. 17–26. – DOI: https://doi.org/10.21303/2504-5679.2021.001854.en_US
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/29784
dc.language.isoenen_US
dc.subjectkallistatinen_US
dc.subjectnon-alcoholic fatty liver diseaseen_US
dc.subjectnon-alcoholic steatohepatitisen_US
dc.subjecthypertensionen_US
dc.subjectIL-10en_US
dc.subjectIL-1βen_US
dc.titleIL-1β and IL-10: diagnostic and prognostic potential of cytokines in the assessment of progression of non-alcoholic fatty liver disease in patients with hypertensionen_US
dc.typeArticleen_US

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