Features of dental status and metabolism in children with early childhood caries against the background of connective tissue dysplasia

Abstract

To assess the dental status of infants suffering from connective tissue dysplasia, with the analysis of some aspects of hydrocarbon and amino acid metabolism (blood, urine) and internal organs status. Materials and methods: 81 infants (aged 14 – 36 months) with multiple dental caries were examined. Among them 39 infants were suffered from connective tissue dysplasia. Results: High prevalence of caries in infants against the background of connective tissue dysplasia compared to their peers in the control group (p <0.05). Thus, the caries intensity index (cf) and the caries intensity growth index (CIGI) are high in all age groups. Disorders of amino acid and carbohydrate metabolism were observed in infants of the main group. Thus, simultaneous increase of amino acids in the blood and urine was observed in 34 children of the main group in different age groups, and simultaneous increase of amino acids in the blood and urine and carbohydrates in the urine was observed in 25 children in different age groups. In infants of the main group the ultrasound examination of abdominal organs revealed changes in the liver, gallbladder, spleen, pancreas and kidneys. Conclusions: When carrying out endogenous prophylaxis of dental caries in infants with connective tissue dysplasia, it is necessary to take into account the internal organs’ status and thin-layer chromatography data of amino acids and carbohydrates in the blood and urine and to prescribe peroral drugs together with the doctors geneticists.