Histological evaluation of therapeutic effects of dexpanthenol composition with ceramides in rats with skin burn injury
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Date
2018-09
Authors
Butko, Yaroslava
Ulanova, Vera
Tkacheva, Oksana
Mishchenko, Oksana
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Journal ISSN
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Abstract
The objective of our research was histological evaluation of
therapeutic effects in case of burn injury in rats.
Experiment was conducted on 84 test rats with burn injury of
III-A stage. Therapeutical effect of studied medicines was evaluated using histological methods.
Results achived gave evidence that on 18-th day of treatment
with ceremids cream and dexpanthenol with ceramids cream
the level granulation tissue maturing increased by 1,4 and 1,7
times and intensity of burn injury epithelization rose by 1,5 and
1,9 times in comparison with non-treated animals. Therapeutic
effect of dexpanthenol with ceramids cream signifcantly overcome action of «Bepanten» cream.
Thus, experiment done proved efciency of ceramids use in
cream composition with dexpanthenol as one of the therapeutic
methods aimed at increase of skin burn injury healing activation.
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Keywords
burn, injury, dexpanthenol, ceramids, healing, injury
Citation
Histological evaluation of therapeutic effects of dexpanthenol composition with ceramides in rats with skin burn injury / Y. Butko, V. Ulanova, O. Tkacheva, O. Mishchenko // Georgian medical newHistological evaluation of therapeutic effects of dexpanthenol composition with ceramides in rats with skin burn injury / Y. Butko, V. Ulanova, O. Tkacheva, O. Mishchenko // Georgian medical news. – 2018. – № 9 (282). – Р. 134–149.