Immunoinflammatory activation in hypertensive patients with prediabetes

Abstract

The aim of the research: to study the levels of inflammatory cytokin interleukin-6 in conjunction with the parameters of lipid metabolism, in patients with hypertension depend on prediabetes presence. Methods. 94 hypertensive patients were examined. Common clinical investigations were provided. Interleukin-6 plasma level detected using ELISA (BSM). Data is represented as Me (Q25-Q75). Kruskal-Wallis and median test were used, р <0,05. Results. Patients were divided into two groups depend on the presence prediabetes. The 1 group consisted of hypertensive patients without prediabetes. The 2 group included hypertensive patients with prediabetes. Hypertensive patients were characterized by increased interleukin-6 activity (18,81 (13,14-26,69) pg/ml). In hypertensive patients with prediabetes decrease interleukin-6 activity (13,94 (11,00-16,94) pg/ml) were found. The hypertension is accompanied by dyslipidemia, characterized by increased levels of total cholesterol 5,67 (4,96- 7,11) mmol/L, triglyceride 2,75 (2,56-3,01) mmol/L, low-density lipoprotein-cholesterol 0,98 (0,83-1,35) mmol/L and decreased levels of highdensity lipoprotein-cholesterol 3,51 (2,77-4,54) mmol/L, it was most expressed in patients with hypertension of the 1 group. Conclusions. According to the obtained results, interleukin-6 plasma level is increased in patients with hypertension, suggesting that the haemodynamic stress caused by elevated blood pressure is sufficient incentive to the growth secretion of these cytokines. The hypertension is accompanied by dyslipidemia, characterized by increased levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol and decreased levels of highdensity lipoprotein-cholesterol,it was most expressed in patients with hypertension of the 1 group. Significant positive relationships between interleukin-6 and parameters of lipid metabolism in patients with hypertension and prediabetes were detected.