Interactions of RANKL, osteoprotegerin and adipokines in regulation of bone remodeling in experimental chronic kidney function disorder

Abstract

RANKL and osteoprotegerin are the key cytokines of the axis regulating not only bone remodeling but also bone-kidney in- terrelations. They are connected with adipokines in the regulatory actions. The aim of the article was to investigate the role of the main parts of RANK-RANKL-osteoprotegerin axis and cytokines of additional link of regulatory network – adiponectin and visfatin and the interrelationship of these cytokines in chronic kidney disorder model in rats. Chronic kidney disorder model was created in the rats 12 weeks after intramuscular 50 % glycerol injection-induced acute kidney injury. RANKL, osteoprotegerin, adiponectin and visfatin levels was measured using ELISA. Increase of all cytokines and changes of their interrelations has been revealed in rats with chronic kidney disorder model. Conclusion was made that effects of the cytokine axis where RANKL is a trigger in the regulation network of intercon- nections «bone – kidney» has inflammatory character, so as visfatin effect, and adiponectin has opposite preserving bone effect.