Effectiveness of intravenous Isoniazid and Ethambutol administration in patients with tuberculosis meningoencephalitis and HIV infection
Date
2019-08
Authors
Butov, Dmytro
Feshchenko, Yurii
Kuzhko, Mykhailo
Gumeniuk, Mykola
Yurko, Kateryna
Grygorova, Alina
Tkachenko, Anton
Nekrasova, Natalia
Tlustova, Tetiana
Kikinchuk, Vasyl
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A significant improvement in the clinical symptoms and X-ray signs in patients treated intravenously with isoniazid and ethambutol was observed and compared to group 2. The sputum Mycobacterium tuberculosis positivity was observed during the second month of the treatment in 25.0% of patients from group 1 and 76.1% of the patients from the control group (p=0.003). In addition, nine patients (39.1%) died up to 6 months when isoniazid and ethambutol were prescribed intravenously compared with 22 (70.9%) in group 2 (p=0.023). In patients with acute progressive form of tuberculosis/tuberculous meningoencephalitis with HIV, the intravenous isoniazid and ethambutol treatment was more effective than oral isoniazid and ethambutol treatment at 2 months of intensive treatment in sputum conversion as well as in clinical improvement, accompanied by significantly higher mean serum concentrations. In addition, the mortality rate was lower in intravenous isoniazid and ethambutol treatment compared to oral treatment.
Description
Keywords
tuberculosis, tuberculous meningitis, Human immunodeficiency virus (HIV), treatment, Isoniazid, Ethambutol
Citation
Effectiveness of intravenous Isoniazid and Ethambutol administration in patients with tuberculosis meningoencephalitis and HIV infection / D. Butov, Y. Feshchenko, M. Kuzhko, M. Gumenuik, K. Yurko, A. Grygorova, A. Tkachenko, N. Nekrasova, T. Tlustova, V. Kikinchuk, A. Peshenko, T. Butova // Tuberculosis and Respiratory Diseases. – 2019. – Vol. 82, issue 20. – P. 1–8.