Endothelial dysfunction parameters in patients with metabolic dysfunction-associated steatotic liver disease and arterial hypertension comorbide course

Abstract

Currently metabolic dysfunction-associated steatotic liver disease (MASLD) is considered to be one of the diseases associated with metabolic disorders, including violations of carbohydrate metabolism, coupled with obesity, insulin resistance and endothelial dysfunction (ED). The presence of MASLD and arterial hypertension (AH) comorbide course is believed to be associated with cardiovascular disease (CVD) increased risk. Oxidative stress development is the key factor in the emergence ED – the process of cell free radicals cumulation adversely affecting it’s function and membrane integrity. ED occupies a prominent place in the pathogenetic mechanisms of CVD and chronic systemic inflammation development. According to a number of researches, a series of vascular inflammation markers being significant CVD risk factors were reported: levels of fibrinogen, C-reactive protein (CRP), uric acid and endothelial nitric oxide synthase (eNOS).