The impact of occupational contact with formaldehyde on the development of leukemia

Abstract

The relevance is due to the widespread use of formaldehyde in departments and units of morphological profiles, its constant presence in work areas, which determines prolonged chronic exposure to employees. The aim of the study: To examine and determine the risks of developing dysfunctions of the hematopoietic system under the influence of formalin-containing substances by analyzing their toxicological, carcinogenic, and genotoxic properties. Materials and methods: Review and analysis of scientific and methodological periodicals. Results and conclusions: According to research findings and the analyzed literature, it was revealed that formaldehyde is a highly reactive chemical substance used in many fields of activity. According to international classifications of associations studying malignant neoplasms of the nasopharynx and leukemia, it is classified as a Group 1 carcinogen. However, the relationship between formaldehyde exposure and leukemia incidence remains a debatable issue. Genetic changes caused by oxidative stress and formaldehyde may disrupt the function of the hematopoietic system and are likely to lead to leukemia. There are genes believed to be susceptible to formaldehyde exposure and associated with the development of leukemia