Experimental study of the antipyretic effect of oxicams and their compositions with caffeine
Date
2018-09-30
Authors
Syrova, Ganna
Lukianova, Larysa
Kalinenko, Olga
Vodolazhenko, Maria
Petiunina, Valentina
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The experimental study of the influence of caffeine on the antipyretic activity of
oxicams in rats was carried out. Meloxicam, piroxicam and their adjuvant caffeine were selected as
drugs. According to the results of experimental studies, it was found that meloxicam has the highest
antipyretic activity (89,24 %) in 3 hours after administration and exceeded the antipyretic activity of the
reference drug. Addition of caffeine to meloxicam did not promote increasing of the meloxicam
antipyretic activity, so this composition is considered inappropriate in relation to its antipyretic effect.
The antipyretic activity of piroxicam was lower comparing to the reference drug diclofenac sodium.
Addition of caffeine to piroxicam promotes increasing of the piroxicam antipyretic activity in 3 hours
after administration of the drug. This exceeded the piroxicam antipyretic activity in 1,3 times but did not
reach diclofenac sodium activity. The results of experimental studies can become the basis for the
creation of new domestic combined medicines.
Description
Keywords
meloxicam, piroxicam, caffeine, antipyretic effect, pharmaceutical composition
Citation
Experimental study of the antipyretic effect of oxicams and their compositions with caffeine / G. O. Syrova, L. V. Lukianova, O. S. Kalinenko, M. O. Vodolazhenko, V. М. Petiunina // International Trends in Science and Technology : Proceedings of the VI International Scientific and Practical Conference, Warsaw, Poland, September 30, 2018 / RS Global Sp.z O.O. – Warsaw, 2018. – Vol. 3. – P. 10–14.