Morphological assessment of the lungs in post-COVID-19 syndrome: analysis of autopsy material
dc.contributor.author | Myroshnychenko, Mykhailo | |
dc.contributor.author | Pasiyeshvili, Nana | |
dc.contributor.author | Kapustnyk, Nataliia | |
dc.contributor.author | Markovskiy, Volodymyr | |
dc.contributor.author | Kalashnyk-Vakulenko, Yuliia | |
dc.contributor.author | Zaytseva, Olga | |
dc.contributor.author | Bondarenko, Maryna | |
dc.contributor.author | Morozov, Oleksandr | |
dc.contributor.author | Molodan, Dmytro | |
dc.date.accessioned | 2023-06-03T17:11:40Z | |
dc.date.available | 2023-06-03T17:11:40Z | |
dc.date.issued | 2023 | |
dc.description.abstract | The aim was to reveal the morphological features of the lungs in post-COVID-19 syndrome. Materials and methods: The material of the study was autopsy material – fragments of the lung tissue from 96 deceased (59 men and 37 women). During the lifetime, all patients had in anamnesis COVID-19 of varying severity, and after the treatment of this infection, they had various manifestations of respiratory failure until death. The average duration of the post-COVID-19 period was 148.6±9.5 days. Based on the severity of COVID-19 in anamnesis, all cases were divided into three groups. Group 1 included 39 cases with mild COVID-19 in anamnesis. Group 2 included 24 cases with moderate severity of COVID-19 in an¬amnesis. Group 3 included 33 cases with severe COVID-19 in anamnesis. Histological, histochemical, morphometric and statistical research methods were used. Results: Morphological features of the lungs in post-COVID-19 syndrome were the presence of pneumosclerosis; focal-diffuse immune cells infiltration; emphysematous and atelectatic changes; degenerative-desquamatic changes in the alveolar epithelium; metaplastic changes of connective tissue; dystrophic calcification; dystrophic, metaplastic and dysplastic changes in the epithelial layer of bronchial tree; hemodynamic disorders. Pneumosclerosis, focal-diffuse immune cells infiltration, alterative changes in the alveolar epithelium, emphysematous and atelectatic changes, hemodynamic disorders increased with an increase the severity of COVID-19. Metaplastic changes of connective tissue, dystrophic calcification, dystrophic, metaplastic and dysplastic changes in epithelial layer of bronchial tree did not depend on the severity of the infection. Conclusions: The changes identified by the authors help to explain pulmonary manifestations of post-COVID-19 syndrome. They should be the basis for the oncological alertness formation among doctors, the development of rehabilitation and treatment measures for such category of patients. | en_US |
dc.identifier.citation | Morphological assessment of the lungs in post-COVID-19 syndrome: analysis of autopsy material / M. S. Myroshnychenko, N. M. Pasiyeshvili, N. V. Kapustnyk, V. D. Markovskiy, Yu. M. Kalashnyk-Vakulenko, O. V. Zaytseva, M. A. Bondarenko, O. V. Morozov, D. V. Molodan // Wiadomości Lekarskie Medical Advances. – 2023. – No. 76 (5 p. 1). – P. 1030–1037. | en_US |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/32153 | |
dc.language.iso | en | en_US |
dc.subject | lungs | en_US |
dc.subject | autopsy | en_US |
dc.subject | post-COVID-19 syndrome | en_US |
dc.title | Morphological assessment of the lungs in post-COVID-19 syndrome: analysis of autopsy material | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 3. Morphological assessment of the lungs.pdf
- Size:
- 20.25 MB
- Format:
- Adobe Portable Document Format
- Description:
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 11.22 KB
- Format:
- Item-specific license agreed upon to submission
- Description: