The participation angiotensinogen polymorphism Met235Thr gene in metabolic disorders in patients with coronary artery disease and obesity

Abstract

Purpose of the study. The article estimated the participation of angiotensinogen gene polymorphism Met235Thr in metabolic disorders in patients with coronary artery disease and obesity. Conclusions. Combined for coronary artery disease and obesity is characterized by hyperinsulinemia and insulin resistance against the background of normoglycemia, which is associated with the T/T genotype polymorphism M235T gene angiotensinogen. The positive relationship of body mass index and the volume of the neck with unfavorable homozygous T allele carriage M235T angiotensinogen gene in patients with coronary artery disease and obesity. It is proved that different variants of the gene M235T polymorphism genotypes angiotensinogen does not affect lipid metabolism in patients with coronary artery disease and concomitant obesity.