Laboratory diagnosis drug allergy. Part 1. Methodology for determining the specific immunoglobulins to drugs, mediators and cytokines
Date
2013
Authors
Бабаджан, Володимир Данилович
Кузнецова, Л.В.
Кравчун, Павло Григорович
Риндіна, Наталія Геннадіївна
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Allergic inflammation of the skin is the basis of drug allergies, mucous
membranes and other tissues and organs damage, it is due to the synthesis
of immune factors in the body that can interact with drugs or their metabolites.
The vast majority of allergic reactions is registered on antibiotics, local
analgetics, nonsteroidal antiinflammatory drugs, heterologous serums, radiopaque
agents, protein drugs of human blood, vaccines, enzymes, vitamins,
tranquilizers, antidiabetic preparations, psychoactive preparations, ACE
inhibitors, antiarrhythmic drugs. However any medicinal substance can
cause drug allergy.
The indications for laboratory examination of patients with drug
intolerance are: anaphylactic shock, severe toxikodermia in anamnesis
of an unknown drug and the need for drug therapy, significant lesions
of the skin and the need of a medication; during using of glucocorticoids,
antihistamines, necessary the introduction of potentially harmful drugs,
in the early childhood, a high level of sensitization of patients, continuously
relapsing course of disease; polyvalent sensitization, where there is
no possibility of testing in vivo directly with all potential allergens in a
limited period of examination; dramatically altered reactivity of the
skin; false-positive or false-negative result in skin testing, urticaria
autographism.
In order to identify immediate hypersensitivity use the following in vitro
tests: determination of the activity of tryptase in the serum in order
to determine
the presence of mast cell degranulation, the definition
of the concentration of specific IgE in serum, holding basophil activation
test in the presence of a potential allergen.
Description
Keywords
in vitro-diagnostic, medical allergies, total IgE, specific IgE, ELISA, chemiluminescence analysis, multiple alergosorbent test
Citation
Laboratory diagnosis drug allergy. Part 1. Methodology for determining the specific immunoglobulins to drugs, mediators and cytokines / V. D. Babadzan, L. V. Kuznetsova, P. G. Kravchun, N. G. Ryndina // Астма та алергія. – 2013. – № 3. – С. 21–27.