Serum markers of connective tissue metabolism in progression of chronic heart failure in patients with chronic obstructive pulmonary diseasecombined with arterial hypertension
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Date
2015-11-05
Authors
Дєлєвська, Валентина Юріївна
Кадикова, Ольга Ігорівна
Dielievska, Valentyna
Kadykova, Olga
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Abstract
Objective: To investigate the changes of protease-antiprotease system in patients with chronic obstructive pulmonary disease (COPD) in combination with arterial hypertension (AH) while progression of chronic heart failure (HF). Conclusions. The progression of HF in patients with AH and COPD is accompanied by the decrease of the proteolysis inhibitor α2-macroglobulin along with high activity of connective tissue degradation processes as observed by increased MMP-9. The observed protease-antiprotease imbalance in patients with AH and COPD causes the changes in extracellular matrix proteins metabolism, resulting in myocardial remodeling, that underlies the pathogenesis of HF.
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Keywords
arterial hypertension, chronic heart failure, chronic obstructive pulmonary disease, protease-antiprotease system, MMP-9
Citation
Dielievska V. Yu. Serum markers of connective tissue metabolism in progression of chronic heart failure in patients with chronic obstructive pulmonary diseasecombined with arterial hypertension / V. Yu. Dielievska, O. I. Kadikova // Хронічні неінфекційні захворювання: заходи профілактики і боротьби з ускладненнями : матеріали науково-практичної конференції з міжнародною участю, Харків, 5 листопада 2015 р. / НАМН України, ДУ «Національний інститут терапії ім. Л. Т. Малої НАМН». – Харків, 2015. – С. 66.