Immunohistochemical characteristic of skin in patients with psoriasis and correction of the revealed disorders

Abstract

The purpose of the research is determination of role of inhibitors of cellular cycle in pathogenesis of psoriasis and efficacy evaluation for pathogenetic mechanisms of therapy. For the purposes of study of cytological characteristic of hyperprolipherative processes at the inhibitors of cellular cycle level in skin of diseased patients with pso¬riasis at steady state and progressive state a biopsy of the plaque skin was performed. On the basis of this research evaluation of pathogenetic mechanisms during psoriasis at the inhibitors of cellular cycle level was realized, proteins (p16, p19, p21, p53) expression in psoriatic patient's skin before and after therapy was evaluated.