Влияние аторвастатина и розувастатина на остаточную реактивность тромбоцитов при приеме клопидогреля у больных ишемической болезнью сердца и сахарным диабетом 2 типа после перенесенного острого коронарного синдрома
Date
2017
Authors
Kochubiei, Oksana
Кочубєй, Оксана Анатоліївна
Кочубей, Оксана Анатольевна
Оврах, Тамара Геннадиевна
Серик, Сергей Андреевич
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In patients with ischemic heart disease and type 2 diabetes
mellitus in 4-6 weeks after acute coronary syndrome
(ACS) on stable dual antiplatelet therapy (DAPT) with
aspirin and clopidogrel co-adminstrated with rosuvastatin
residual platelet reactivity on adenosine diphosphate was
higher than in patients receiving atorvastatin. However,
the rate of high residual on-clopidogrel treatment platelet
reactivity (RCPR) in rosuvastatin-treated patients exceeded
the rate of high RCPR in atorvastatin-treated patients
insignificantly. In 6 months after ACS residual platelet
reactivity did not differ between the groups. After 12
months of DAPT platelet reactivity increased as compared
to baseline values both in patients receiving rosuvastatin
and in patients receiving atorvastatin without switching.
In patients, randomly switching from one statin type to
another at 6 month of treatment, platelet reactivity did
not change significantly in comparison to baseline and the
prevalence of high RCPR was lower than in patients receiving
statins without switching. Thus, in patients with diabetes
with ACS on DAPT with acetylsalicylic acid and clopidogrel
statin treatment should be started with atorvastatin and in 6
months after ACS atorvastatin should be switched to rosuvastatin.
This approach will provide lower RCPR within at
least first 4-6 weeks after ACS and prevent RCPR increase
during 12 months of DATT use in this patients group.
Description
Keywords
acute coronary syndrome
Citation
Оврах Т. Г. Влияние аторвастатина и розувастатина на остаточную реактивность тромбоцитов при приеме клопидогреля у больных ишемической болезнью сердца и сахарным диабетом 2 типа после перенесенного острого коронарного синдрома / Т. Г. Оврах, С. А. Серик, О. А. Кочубей // Медицинские новости Грузии. – 2017. – № 4 (265). – С. 7–14.