Hepcidin in anemic patients with chronic heart failure and chronic kidney disease

dc.contributor.authorТитова, Ганна Юріївна
dc.contributor.authorРиндіна, Наталія Геннадіївна
dc.contributor.authorКравчун, Павло Григорович
dc.contributor.authorTytova, Ganna
dc.contributor.authorRyndina, Natalia
dc.contributor.authorKravchun, Pavlo H.
dc.date.accessioned2015-11-05T09:28:41Z
dc.date.available2015-11-05T09:28:41Z
dc.date.issued2015-09-23
dc.description.abstractAnemia has been recognized as a very common and serious comorbidity in chronic heart failure (CHF) and chronic kidney disease (CKD), with a prevalence ranging from 10 to 79 %, depending on diagnostic definition, disease severity and patient characteristics. A clear association of anemia with worse prognosis has been confirmed in multiple heart failure trials. The pathogenesis of anemia in CHF has yet to be fully elucidated, but is likely to be complex.The origins of defective iron homeostasis, which is a major cause of anemia in patients with chronic heart failure, compared with chronic kidney disease are unknown. The aim – to understand role of the inflammatory mediators:interleukin (IL)-6 and hepcidin in iron deficiency in CHF and CKD. Conclusion. Defective iron homeostasis in anemic CHF and CKD patients is associated with an immune-mediated up-regulation in hepcidin expression, central mediator that inhibits iron release and intestinal iron absorption.ru_RU
dc.identifier.citationTytova G. Hepcidin in anemic patients with chronic heart failure and chronic kidney disease / G. Tytova, N. Ryndina, P. Kravchun // Український кардіологічний журнал. – 2015. – Додаток 1: Матеріали XVI Національного конгресу кардіологів України, Київ, 23-25 вересня 2015 р. – С. 178.ru_RU
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/10565
dc.language.isoenru_RU
dc.subjectchronic heart failureru_RU
dc.subjectchronic kidney diseaseru_RU
dc.subjectanemiaru_RU
dc.subjectinterleukin-6ru_RU
dc.subjecthepcidinru_RU
dc.titleHepcidin in anemic patients with chronic heart failure and chronic kidney diseaseru_RU
dc.typeThesisru_RU

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