Morphological peculiarities of cerebral injury in polyomavirus infection in HIV-positive individuals
Date
2022
Authors
Zhelezniakova, Natalia
Bondarenko, A.
Katsapov, D.
Pasiieshvili, Tamara
Bocharova, Tetiana
Gargin, Vitaliy
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The article presents information about the study of morphological features in progressive multifocal leukoencephalopathy caused by polyomavirus infection in HIV-infected individuals. A study of sectional material (the brain) was carried out. After routine proceeding and histological staining, the slides were studied under Olympus BX41 microscope, followed by a morphometric examination. According to neuroimaging methods, the presence of multiple foci in the brain may be caused by the presence of several etiological factors: JCV, BKV, EBV, T. gondii, and C. neoformans, which requires mandatory laboratory confirmation. Morphological changes in the brain in PML caused by JCV and BKV are characterized by areas of demyelinated lesions 2-3 mm in size with a tendency to merge, with significant areas of white matter affected and degenerative changes predominantly in the juxtacortical/subcortical white matter.
Description
Keywords
JC-virus, BK-virus, polyomavirus infection, Human immunodeficiency virus (HIV)
Citation
Morphological peculiarities of cerebral injury in polyomavirus infection in HIV-positive individuals / A. V. Bondarenko, D. V. Katsapov, T. M. Pasiieshvili [at al.] // Azerbaijan Medical Journal. – 2022. – Vol. 3. – P. 101–107.