Wound healing effect of "Prolidoxid" and "Dexpanthenol with ceramides": a comparative study based on the model of chemical burns with expressed alterative skin processes

Abstract

Pharmacotherapy of chemical skin injuries remains an urgent issue today due to its serious health consequences and possible development of complications. Topical treatment is one of the most effective methods of wound treatment using hydrophilic ointments and creams. For now, range of hydrophilic medicinal products with a broad spectrum of action is limited. That is why a search and development of new hydrophilic ointments and creams remains an urgent challenge. The aim. The aim of this research was to study effectiveness of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” on the experimental chemical burn model in rats. Materials and methods. Wound healing effect of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” was proved by the study of planimetric and hematological parameters on the model of acetic acid burns in rats. Results. Using animal model of chemical burns it was found that ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” accelerate wound healing on Day 5 and Day 6, consequently, compared to untreated control animals, but in comparison with the action of reference medicine wounds were healed two days faster. Hematological parameters showed that studied medicines inhibit inflammation and reactivate blood rheological properties. Conclusions. The results suggest that effectiveness of cream “Dexpanthenol with ceramides” is higher than for onecomponent cream “Dexpanthenol”, but ointment “Prolidoxid” exceeds therapeutic action of ointment “Wundahyl” as reported by hematological and planimetric parameters