Metabolic profile of serum fatty acids in patients with comorbidity of chronic obstructive pulmonary disease and chronic pancreatitis

Abstract

Objective: study of blood serum fatty acid metabolic profile in patients with comorbidity of COPD and chronic pancreatitis. Materials and methods. 238 patients were examined, of them 131 with combined COPD and chronic pancreatitis and 107 with isolated COPD run. In study of fatty acid spectrum biological materials were prepared and gas chromatography analysis of blood serum lipid fatty acid spectrum performed according to methodology by L.V.Sazonenko et al. Results. The study showed that COPD exacerbation was accompanied with by changes in contents of particular fatty acids both in patients with isolated COPD and in patients with comorbidity in comparison with almost healthy patients. In comparison of values for isolated COPD patients and comorbidity of COPD and chronic pancreatitis patients unidirectional deviations in concentrations of basic FAs were observed in both groups. Although concentrations of basic FAs mostly did not have probable discrepancies, nevertheless, concentration changes of stearic and linoleic acids were significantly more expressed, which caused saturation level reduction and increased unsaturation of fatty acids. Conclusions. The presence of concomitant chronic pancreatitis in patients with COPD substantially strengthened the expression of FAs spectrum deviations due to increase of unsaturation level and the sum of PSFAs which is indicative of lipid peroxidation processes intensification, and this may be treated as one of additional factors of pathology progressing.