Genetic predictors of cardiovascular complications escalation in patients with asthma

Abstract

One of the serious asthma complications is the defeat of the cardiovascular system, which may take the form of dismetabolic cardiomyopathy, myocardiosclerosis or pulmonary heart. In this case clinical symptoms of these nosologies exacerbate the underlying disease, which manifests the formation of severe asthma refractory to conventional therapy. It was found that the predictor of these changes is endothelial dysfunction, one of the markers which can be considered is polymorphism of angiotensinconverting enzyme (ACE) gene.