Blood film indexes in offspring with prenatal influence of experimental maternal chronic genitourinary system inflammatory process caused by Proteus mirabilis and Streptococcus pyogenes uroisolates

Abstract

The risk of complications is associated with the severity of chronic inflammatory process in pregnant woman, and affects the health of the child. Kidney damage, which is associated with exacerbation of chronic genitourinary system inflammatory processes of bacterial etiology during pregnancy, is a common and global health problem. Aim: The aim was to determine the features of blood film indexes changes in offspring with prenatal influence of experimental maternal chronic bacterial genitourinary system inflammatory process. Materials and methods. The blood serum of WAG rats born from mothers with chronic bacterial genitourinary system inflammatory process was analyzed. The results were analyzed using the Software Statistica 7. Results It was established that the development of inflammatory process with a decrease in eosinophils count and lymphocytes percentage and an increase in neutrophils number took place, accompanied by increase in monocytes percentage in 7-day-old and 1-month-old rats of both experimental groups, in 2-month-old rats the monocytes content was decreased, especially in Ib subgroup. Leukocytosis reached its maximum severity, especially in 1- and 2-month-old rats of Ia subgroup. The number of neutrophils in 7-day-old rats of Ia and Ib subgroups increased by 2.3 times and 1.4 times, respectively, compared with the control. In 1-month-old rats of Ia subgroup, the number of neutrophils was increased by 1.3 times. The difference was that the level of segmented neutrophils remained below the control values in 2-month-old rats of Ia subgroup and in 1- and 2-month-old rats of Ib subgroup due to the increased rod-shaped neutrophils count. Conclusions. Analysis of leukograms allows timely detection of the risk of kidney pathology in offspring with prenatal influence of experimental maternal chronic genitourinary system inflammatory process and can be one of the prognostic criteria for the outcome of the pathological process in kidneys.