Monocyte chemo attractant protein-1 in patients with chronic heart failure of different functional class with type 2 diabetes

Abstract

The aim of the study was to assess the dynamics of monocyte chemoattractant protein-1 in patients with chronic heart failure of different functional classes depending on the presence or absence of concomitant type 2 diabetes. 95 patients with chronic heart failure II - III FC were examined due to coronary heart disease who were treated at the cardiological department of the Kharkiv City Clinical Hospital № 27 (mean age 65,13 ± 8,66 years). The first group included 52 patients with chronic heart failure with type 2 diabetes, the second - 43 chronic heart failure patients without type 2 diabetes. Research was excluded patients with acute coronary syndrome, acute myocardial infarction. 65 patients of patients had II NYHA FC, 30 patients - III FC. Among the 1st group 31 patients had II NYHA FC, 12 - III FC. In 2nd groups of patients, 40 patients had II NYHA FC, 12 patients had FC III. Concentration of proinflammatory cytokine interleukin-1β and fibrosis factor monocyte chemoattractant protein-1 were determined by ELISA (enzyme-linked immunosorbent assay). In patients with chronic heart failure in presence or absence of type 2 diabetes increase in the profibrotic parameter monocyte chemoattractant protein-1 and proinflammatory cytokine interleukin-1β were increasing in parallel with NYHA FC increasing. Presence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1β and monocyte chemoattractant protein-1, compared with patients without diabetes in the presence of the same NYHA FC of chronic heart failure.