Pathological and histological examination of selected skeletal sites in deforming osteodystrophy

Abstract

Deforming osteodystrophy is a rare but clinically significant skeletal disease characterized by chronic disruption of bone remodeling processes. Lesions in certain skeletal regions cause pronounced morphological changes accompanied by deformities and loss of functional stability of the bones. Pathoanatomical and histological studies allow for detailed investigation of these processes, clarification of pathogenetic mechanisms, and provide a foundation for improving diagnostic approaches. The aim of the study: To characterize morphological changes in specific skeletal regions in deforming osteodystrophy through pathoanatomical and histological analysis, to determine the features of bone remodeling and their significance for diagnosis and understanding of the disease pathogenesis. Materials and methods: Theoretical: review and analysis of scientific and methodological literature. Practical: original research