Experimental research of allergenic effect of coformulated antihypertensive drug

Abstract

The aim of the research is to study the allergenic effect of a new coformulated antihypertensive COMBI drug that contains bisoprolol, lisinopril and indapamide. Therefore, COMBI drug in the fixed doses along with overlapping sensitization with integral indicators, intradermal samples, diagnostic tests (reaction of specific agglomeration of leukocytes, the reaction of alteration of neutrophils), number of blood eosinophils has no allergenic effect. The absence of specific sensitization isconfirmed with the negative conjunctival sample of guinea pigs.