Peculiarities of pathogenesis of complications with account of immuno-physiological disorders in acute response to trauma

Abstract

Mechanisms associated with the development of systemic inflammation response syndrome (SIRS) are of great importance in the progression of multiple organ dysfunction syndrome, traumatic disease and progression of pyoinflammatory complications. This study has been shown that period of acute response to trauma corresponds to the period of shock and early postshock period (first two days), which is characterized by hypovolemia and perfusion deficiency. To restore homeostasis allelically-determined powerful energetic mechanisms of urgent adaptation (hypermetabolism), changing the character of carbohydrate, protein and fat metabolism, are involved. Above-noted mechanisms become exhausted that results in decompensation (fatal case) or at adequate treatment functional dominance switches on the mechanisms of long-term adaptation, ensuring restoration of sustainable living. The character of the early and late complications is predetermined by the degree of immunogenic and metabolic disturbances.