Prognostic Value of Individual Tumor Cells in Bone Marrow, Lymph Nodes in Patients with Non-small Cell Lung Carcinoma
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The results of the examination of the bone marrow and distant lymph nodes for the presence of circulating tumor cells in 83
patients with non-small cell lung cancer T2-3N0M0, who had been radically operated, are given. Isolated tumor cells were
determined by immune cytochemical and immune histochemical methods with the monoclonal antibodies to cytokeratins. Isolated
tumor cells were detected in bone marrow in 30.1% and in lymph nodes in 20.5% of patients. The simultaneous presence of isolated
tumor cells in bone marrow and lymph nodes was found in 18.1% of patients that significantly reduced the 3-year survival rate.
Isolated tumor cells can be considered as a negative prognostic factor that must be taken into account when choosing the adjuvant
treatment of lung carcinoma.
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Prognostic Value of Individual Tumor Cells in Bone Marrow, Lymph Nodes in Patients with Non-small Cell Lung Carcinoma / V. I. Starikov, A. S. Khodak, V. V. Makarov, А. О. Syrovaya, V. A. Makarov, О. А. Zavadaet // International Journal of Pharmaceutical Sciences Review. – 2017. – № 45 (1). – P. 172–174.