Various origins pneumonia express diagnosis during the war in Ukraine

Abstract

Introduction. The study of the serum level of PCT and sTREM has been proposed as markers of bacterial infection, which have been applied for the early differentiation of processes of viral and bacterial etiology. Aim. Determination of express markers for predicting the effectiveness of empiric antibiotic therapy in patients with IPD. Materials and methods. Study groups with viral pneumonias, as well as bacterial etiology caused by Haemophilus influenzae, groups of patients with ChOPd I-II III-IV stages were formed. Controls for the studied groups were patients at the stage of remission and a group of healthy individuals without lung pathology and infectious diseases. The specific identification of microorganisms in the clinical material of patients with pneumonia was carried out in two stages: the first stage in the laboratories of the respective hospitals was carried out by the method of HIR and CFT; the second was carried out with the help of specific antibodies by the indirect fluorescence method using a fluorescent microscope and qualitative analysis test kits («Respiratory Tract Profile 1 biochip Mosaics for infectious serology», Medizinische Labordiagnostika AG «euroimmun»). Results. In our study, the serum level of sTREM-1 was used as a criterion for assessing the probability of bacterial infection and, accordingly, increasing the degree of reliability of the prognosis provided by the PCT level study. The expression level of sTREM-1 and PCT were used as markers of bacterial infection for the early differentiation of processes of viral and bacterial etiology. Conclusions. The study of serum levels of PCT and sTREM, which are markers of bacterial infection and are used for early differentiation of processes of viral and bacterial etiology, has demonstrated the prognostic importance of the express assessment method of the infectious process etiology. The obtained results were used in the development of method for predicting the effectiveness of empiric antibiotic therapy in patients with IPD infectious diseases.