Obestatin levels in patients with arterial hypertension and diabetes mellitus type 2 depending on the presence of obesity

Abstract

Comorbidity of arterial hypertension and diabetes mellitus type 2 is associated with high obestatin activity, compared with a group of arterial hypertension patients without diabetes mellitus type 2 and the control group, which suggests the compensatory reaction at this stage. Presence of obesity in patients with arterial hypertension and diabetes mellitus type 2 is accompanied by maladaptive decreasing of obestatin compared with patients without obesity, which can be considered as an important factor in the development and progression of the obesity according anorexic obestatin’s properties.