Nephroprotective Activity of Sodium Poly-(2,5-Dyhidroksyfenilen)-4-Thiosulfate acid Under Acute Renal Injury

Abstract

In the executed work nephroprotective effect of PDТ-Na is setted, which by most indicators exceed action of a reference drug thiotriazoline, manifested in conditions of experimental models of acute renal injury (ARI). According to mechanisms of kidney damage by applied models degree of protective action of PDT-Na in these conditions is different too: It turns out more in the background of the sample kidney damage by the type of crash-syndrome, that is evidence of renal antitoxic mechanism of its protection. Somewhat less this effect is manifested at gentamycine nephropathy, where is nephrotoxic factor accumulation gradually caused similar renal pathology and evidence of connection mechanism of PDT-Na with epithelium protective properties of the drug. Even less severe, but sufficiently, it is observed at the conditions of ethylene glycol model in which kidney disease combined with central nervous system disorders, and causes general antitoxic mechanism of nephroprotective PDT-Na action. In all models of ARI kidney protection is implemended by warning of enzymopathy development and normalization of blood electrolyte, which differ quantitatively. At the same time, common quality properties of PDT-Na, obviously, related to its nonspecific effects relating to anti-hypoxic and antioxidant actions which determine the direction of our further research.