Interleukin-18 and oligomeric matrix protein of cartilage in patients with autoimmune thyroiditis and osteoarthritis

Abstract

Interleukin-18 takes a special place among the immunoregulatory mediators. It is one of the key cytokines in the congenital and acquired immune response formation. Interleukin-18 takes part in the activation of cytotoxic T-lymphocytes, NK cells, macrophages, dendritic cells, thereby "providing" an autoimmune response of the organism. Currently, a cartilage oligomeric matrix protein (COMP) is considered as a marker of cartilage damage. It is a non-collagen matrix protein. Its entry into the blood is correlated with the exchange in the tissue of the cartilage. Interleukin-18 takes a special place among the immunoregulatory mediators. It is one of the key cytokines in the congenital and acquired immune response formation. Interleukin-18 takes part in the activation of cytotoxic T-lymphocytes, NK cells, macrophages, dendritic cells, thereby "providing" an autoimmune response of the organism. Currently, a cartilage oligomeric matrix protein (COMP) is considered as a marker of cartilage damage. It is a non-collagen matrix protein. Its entry into the blood is correlated with the exchange in the tissue of the cartilage.