Assessment of lipid metabolism using cluster analysis in hypertensive patients

Abstract

The aim. To investigate the parameters of lipid metabolism depending on the oncostatin M level based on cluster analysis in hypertensive patients. Methods. 103 hypertensive patients aged 40 to 60 years were examined. All patients underwent complex clinical examination. Following parameters of lipid metabolism were measured. Oncostatin M plasma level detected using ELISA (RayBio). Results: The result of clustering procedures depending on oncostatin M plasma level. 1st cluster was formed 32 patients (31.1%), oncostatin M plasma level was 40.15 (30.65-46.28) pg/ml, 2nd cluster - 19 patients (18.4%), oncostatin M plasma level was 79.41 (50.14-7.,41) pg/ml and 3rd cluster - 52 patients (50.5%), oncostatin M plasma level was 11.72 (10.00-18.63) pg/ml. According to the obtained results, the 1st cluster was characterized by total cholesterol 5,67 (4,74- 6,45) mmol/L, triglyceride 2,75 (2,47-3,15) mmol/L, low-density lipoprotein-cholesterol (LDL)3,45 (2,53-3,86) mmol/L, very low-density lipoprotein-cholesterol (VLDL)1,25 (1,12-1,43) mmol/L, high-density lipoprotein-cholesterol (HDL) 1,05 (0,88-1,37) mmol/L. The 2nd cluster was characterized by total cholesterol 9,64 (7,51-9,64) mmol/L, triglyceride 3,72 (2,78-3,72) mmol/L, LDL 6,33 (4,70-6,33) mmol/L, VLDL 1,69 (1,26-1,69) mmol/L, HDL 1,62 (1,55-1,62) mmol/L. The 3rd cluster was characterized by total cholesterol 5,00 (4,33-5,47) mmol/L, triglyceride 2,37 (1,11-1,78) mmol/L, LDL 3,03 (2,52-3,38) mmol/L, VLDL 1,08 (0,50-1,26) mmol/L, HDL 1,15 (0,91-1,28) mmol/L. Conclusions. In the 1st cluster, we observed the lowest values except of total cholesterol, triglyceride, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol. The 2nd cluster was characterized by the highest values except high-density lipoprotein-cholesterol. We found the lowest levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol, among the 3rd clusters. The combination of adverse pathological changes lipid metabolism in patients 2nd cluster were detected,and oncostatin M plasma level was most expressed in patients 2nd cluster.