Mechanisms of target organ damage in patients with arterial hypertension and obesity

Abstract

In patients with hypertension and its combination with obesity progression of the pathological process may be caused by the inclusion of the immune system in the pathogenesis of diseases. A combination of hypertension and obesity lead to a significant increase CIC in the blood content of examined patients, which indicates activation of immune components, and hence, the progression of the disease. The presence of hypertension and obesity is accompanied by strengthening of autosensibilization processes to target organs and the liver, which provides not only the progression of the disease, but also the continuity of the process. Consequently, the presence of obesity leads to earlier involvement in the process target organs, not only due to hemodynamic and metabolic changes in the body, but also autoimmune disorders.