Desaturation and IL-18/IL-10 ratio as prognostic predictors for adverse right ventricular remodeling

Abstract

Adverse right ventricular (RV) remodeling leads to heart failure that represents an important determinant of outcome in patients with hypertension (HT) combined with chronic obstructive pulmonary disease (COPD). Chronic hypoxia and systemic inflammation contribute to tissue destruction and disruption normal repair and defense mechanisms, resulting in pulmonary vascular remodeling and pulmonary hypertension. We found that desaturation is associated with inflammatory activation and contributes to right heart chambers overload. The cut off level of IL-18/IL-10 ratio 26.64 is an independent prognostic predictor for RV pressure overload in patients with HT stage II in combination with moderate COPD.